This paper (pdf) is a result of a collaboration between the Sharma Lab at Harvard Medical School and the Renz group at Philipps University Marburg. In this work, I developed IDEAL, a method to predict the role of micro-RNAs (miRNAs) in a disease based on their topological impact in the interactome, and not on their fold-change. The method was applied in the case of asthma, based on an experimental setup and validation done by Ayşe Kılıç (a massive work!). We found that a cocktail of 5 miRNAs identified as having large topological impact, but not large expression fold-change, led to a sharp reduction of the asthmatic Th2 phenotype.